BENCE-JONES PROTEIN IN SERUM
نویسندگان
چکیده
منابع مشابه
What's in a name? Bence Jones protein
Plasma cell disorders are important in the differential diagnosis of acute kidney injury and of renal impairment with proteinuria. One or more of several mechanisms can be involved, such as cast nephropathy, deposition of monoclonal immunoglobulins, formation of amyloid fibrils, hypercalcaemia, hyperuricaemia and a variety of tubular syndromes. Various tests, such as serum electrophoresis and i...
متن کاملBence Jones protein in primary systemic amyloidosis.
The recent population-based study by Kyle et al,’ which was the first to provide precise epidemiologic information about primary systemic amyloidosis, reported the demonstration of a monoclonal (M)protein in the serum or urine from 16 of 21 patients (76%) with amyloid of unequivocal Ig origin (AL). However, the number of patients in whom free monoclonal Ig light chain (ie, Bence Jones [BJ] prot...
متن کاملThe Fate of Injected Bence Jones Protein
Bence Jones protein injected into rabbits was excreted rapidly into the urine. The excreted protein retained the physicochemical and immunochemical properties of the injected Bence Jones protein. In spite of the rapid excretion, a significant portion of the injected Bence Jones protein was found to be metabolized. After reinjection of radioactive Bence Jones protein into the donor patient, only...
متن کاملDouble spike in the electropherogram of a myeloma serum, from Bence Jones protein.
Serum from a 71-year-old man with multiple myeloma complicated with renal failure showed a monoclonal IgG lambda. A second spike appearing in the serum protein electropherogram, suggesting a biclonal gammopathy, was found to be due to lambda Bence Jones protein (29.9 g/liter). Lambda Bence Jones protein was also found in smaller concentration (3.8 g/liter) in the urine. Tetramers of Bence Jones...
متن کاملMacroglobulinemia with Bence Jones Proteinuria: Comparison of Urinary Protein and L Chain of Serum Proteins.
Edelman and Gally (1) have recently shown that an individual's Bence Jones proteins are chemically and physically similar to the low molecular weight polypeptides (L chains) obtained by reductive cleavage of his myeloma proteins. Indeed, Putnam (2) has shown that peptide maps of the tryptic digests of oxidized Bence Jones proteins correspond to a portion of the peptide map of similarly treated ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1934
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)75351-9